A Genetic Selection for dinB Mutants Reveals an Interaction between DNA Polymerase IV and the Replicative Polymerase That Is Required for Translesion Synthesis

Translesion DNA synthesis (TLS) by specialized DNA polymerases (Pols) is a conserved mechanism for tolerating replication blocking DNA lesions. The actions of TLS Pols are managed in part by ring-shaped sliding clamp proteins. In addition to catalyzing TLS, altered expression of TLS Pols impedes cel...

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發表在:PLoS Genet
Main Authors: Scotland, Michelle K., Heltzel, Justin M. H., Kath, James E., Choi, Jung-Suk, Berdis, Anthony J., Loparo, Joseph J., Sutton, Mark D.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564189/
https://ncbi.nlm.nih.gov/pubmed/26352807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005507
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