Characterization of three mycobacterial DinB (DNA polymerase IV) paralogs highlights DinB2 as naturally adept at ribonucleotide incorporation

This study unveils Mycobacterium smegmatis DinB2 as the founder of a clade of Y-family DNA polymerase that is naturally adept at incorporating ribonucleotides by virtue of a leucine in lieu of a canonical aromatic steric gate. DinB2 efficiently scavenges limiting dNTP and rNTP substrates in the pres...

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Bibliographic Details
Main Authors: Ordonez, Heather, Uson, Maria Loressa, Shuman, Stewart
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176160/
https://ncbi.nlm.nih.gov/pubmed/25200080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku752
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