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Mycobacterium smegmatis DinB2 misincorporates deoxyribonucleotides and ribonucleotides during templated synthesis and lesion bypass

Mycobacterium smegmatis DinB2 is the founder of a clade of Y-family DNA polymerase that is naturally adept at utilizing rNTPs or dNTPs as substrates. Here we investigate the fidelity and lesion bypass capacity of DinB2. We report that DinB2 is an unfaithful DNA and RNA polymerase with a distinctive...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Ordonez, Heather, Shuman, Stewart
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227753/
https://ncbi.nlm.nih.gov/pubmed/25352547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1027
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