MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma

ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. We identify ATG4B as a substrate of mammalian sterile20-like kinase (STK) 26/MST4. MST4 phosphorylates ATG4B at serine residue 383, which stimulates ATG4B activity and increases autophagic flux....

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Publicado no:Cancer Cell
Main Authors: Huang, Tianzhi, Kim, Chung Kwon, Alvarez, Angel A., Pangeni, Rajendra P., Wan, Xuechao, Song, Xiao, Shi, Taiping, Yang, Yongyong, Sastry, Namratha, Horbinski, Craig M., Lu, Songjian, Stupp, Roger, Kessler, John A., Nishikawa, Ryo, Nakano, Ichiro, Sulman, Erik P., Lu, Xinghua, James, Charles David, Yin, Xiao-Ming, Hu, Bo, Cheng, Shi-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5734934/
https://ncbi.nlm.nih.gov/pubmed/29232556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.11.005
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