Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer–associated P-glycoprotein during ATP hydrolysis

P-glycoprotein (Pgp) is an efflux pump important in multidrug resistance of cancer cells and in determining drug pharmacokinetics. Pgp is a prototype ATP-binding cassette transporter with two nucleotide-binding domains (NBDs) that bind and hydrolyze ATP. Conformational changes at the NBDs (the Pgp e...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Zoghbi, Maria E., Mok, Leo, Swartz, Douglas J., Singh, Anukriti, Fendley, Gregory A., Urbatsch, Ina L., Altenberg, Guillermo A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733581/
https://ncbi.nlm.nih.gov/pubmed/29018094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.814186
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