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Conformational changes of the nucleotide binding domains of P-glycoprotein induced by ATP hydrolysis
P-glycoprotein (Pgp) is a member of the ABC transporter superfamily with high physiological importance. Pgp nucleotide binding domains (NBDs) drive the transport cycle through ATP binding and hydrolysis. We use molecular dynamics simulations to investigate the ATP hydrolysis-induced conformational c...
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| Veröffentlicht in: | FEBS Lett |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7987826/ https://ncbi.nlm.nih.gov/pubmed/33159693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13992 |
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