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Conformational changes of the nucleotide binding domains of P-glycoprotein induced by ATP hydrolysis
P-glycoprotein (Pgp) is a member of the ABC transporter superfamily with high physiological importance. Pgp nucleotide binding domains (NBDs) drive the transport cycle through ATP binding and hydrolysis. We use molecular dynamics simulations to investigate the ATP hydrolysis-induced conformational c...
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| Yayımlandı: | FEBS Lett |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7987826/ https://ncbi.nlm.nih.gov/pubmed/33159693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13992 |
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