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Probing Cholesterol Binding and Translocation in P-glycoprotein
P-glycoprotein (Pgp) is a biomedically important member of the ABC transporter superfamily that mediates multidrug resistance in various cancer types. Substrate binding and transport in Pgp are modulated by the presence of cholesterol in the membrane. Structural information on cholesterol binding si...
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| Publicado en: | Biochim Biophys Acta Biomembr |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6934093/ https://ncbi.nlm.nih.gov/pubmed/31676371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2019.183090 |
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