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Active participation of membrane lipids in inhibition of multidrug transporter P-glycoprotein

P-glycoprotein (Pgp) is a major efflux pump in humans, overexpressed in a variety of cancers and associated with the development of multi-drug resistance. Allosteric modulation by various ligands (e.g., transport substrates, inhibitors, and ATP) has been biochemically shown to directly influence str...

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Pubblicato in:Chem Sci
Autori principali: Kapoor, Karan, Pant, Shashank, Tajkhorshid, Emad
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Royal Society of Chemistry 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115088/
https://ncbi.nlm.nih.gov/pubmed/34084427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc06288j
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