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Active participation of membrane lipids in inhibition of multidrug transporter P-glycoprotein
P-glycoprotein (Pgp) is a major efflux pump in humans, overexpressed in a variety of cancers and associated with the development of multi-drug resistance. Allosteric modulation by various ligands (e.g., transport substrates, inhibitors, and ATP) has been biochemically shown to directly influence str...
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| Udgivet i: | Chem Sci |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Royal Society of Chemistry
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8115088/ https://ncbi.nlm.nih.gov/pubmed/34084427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc06288j |
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