Synthesis and Biological Evaluation of a Series of Bile Acid Derivatives as FXR Agonists for Treatment of NASH

[Image: see text] Farnesoid X receptor (FXR) has become a particularly attractive target for the discovery of drugs for the treatment of liver and metabolic diseases. Obeticholic acid (INT-747), a FXR agonist, has advanced into clinical phase III trials in patients with nonalcoholic steatohepatitis...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Xiao, Hualing, Li, Peng, Li, Xiaolin, He, Haiying, Wang, Jianhua, Guo, Fengxun, Zhang, Jiliang, Wei, Luxia, Zhang, Hongmei, Shi, Yueyuan, Hou, Lijuan, Shen, Liang, Chen, Zhengxia, Du, Chunyan, Fu, Shouliang, Zhang, Pengtao, Hao, Fei, Wang, Ping, Xu, Deming, Liang, Wei, Tian, Xin, Zhang, Aiming, Cheng, Xingdong, Yang, Ling, Wang, Xiangjian, Zhang, Xiquan, Li, Jian, Chen, Shuhui
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733277/
https://ncbi.nlm.nih.gov/pubmed/29259742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00318
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