Discovery of a Novel Selective Dual Peroxisome Proliferator-Activated Receptor α/δ Agonist for the Treatment of Primary Biliary Cirrhosis

[Image: see text] A novel peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist 5c was developed with an EC(50) of 8 nM for PPARα, 5 nM for PPARδ, and >300-fold selectivity against PPARγ (EC(50) = 2939 nM), respectively. Further ADME and pharmacokinetic studies indicated 5c possessed...

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Publicado no:ACS Med Chem Lett
Main Authors: Jiang, Zhigan, Liu, Xing, Yuan, Zhiliang, He, Haiying, Wang, Jing, Zhang, Xiao, Gong, Zhen, Hou, Lijuan, Shen, Liang, Guo, Fengxun, Zhang, Jiliang, Wang, Jianhua, Xu, Deming, Liu, Zhuowei, Li, Haijun, Chen, Xiaoxin, Long, Chaofeng, Li, Jian, Chen, Shuhui
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627728/
https://ncbi.nlm.nih.gov/pubmed/31312410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00189
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