Loss of MutL disrupts Chk2-dependent cell cycle control through CDK4/6 to promote intrinsic endocrine therapy resistance in primary breast cancer

Significant endocrine therapy-resistant tumor proliferation is present in ≥20% of estrogen receptor positive (ER(+)) primary breast cancers and is associated with disease recurrence and death. Here, we uncover a link between intrinsic endocrine therapy resistance and dysregulation of the MutL mismat...

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Udgivet i:Cancer Discov
Main Authors: Haricharan, Svasti, Punturi, Nindo, Singh, Purba, Holloway, Kimberly R., Anurag, Meenakshi, Schmelz, Jacob, Schmidt, Cheryl, Lei, Jonathan T., Suman, Vera, Hunt, Kelly, Olson, John A., Hoog, Jeremy, Li, Shunqiang, Huang, Shixia, Edwards, Dean P., Kavuri, Shyam M., Bainbridge, Matthew N., Ma, Cynthia X., Ellis, Matthew J.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733075/
https://ncbi.nlm.nih.gov/pubmed/28801307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-1179
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