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Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway

At clinically relevant doses, chemotherapeutic S(N)1 DNA methylating agents induce an ATR-mediated checkpoint response in human cells that is dependent on functional MutSα and MutLα. Deficiency of either mismatch repair activity renders cells highly resistant to this class of drug, but the mechanism...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, Yiyong, Fang, Yanan, Shao, Hongbing, Lindsey-Boltz, Laura, Sancar, Aziz, Modrich, Paul
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820822/
https://ncbi.nlm.nih.gov/pubmed/20029092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.076109
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