Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway

At clinically relevant doses, chemotherapeutic S(N)1 DNA methylating agents induce an ATR-mediated checkpoint response in human cells that is dependent on functional MutSα and MutLα. Deficiency of either mismatch repair activity renders cells highly resistant to this class of drug, but the mechanism...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Liu, Yiyong, Fang, Yanan, Shao, Hongbing, Lindsey-Boltz, Laura, Sancar, Aziz, Modrich, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820822/
https://ncbi.nlm.nih.gov/pubmed/20029092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.076109
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky