MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

To avoid mutations in the genome, DNA replication is generally followed by DNA mismatch repair (MMR). MMR starts when a MutS homolog recognizes a mismatch and undergoes an ATP-dependent transformation to an elusive sliding clamp state. How this transient state promotes MutL homolog recruitment and a...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Groothuizen, Flora S, Winkler, Ines, Cristóvão, Michele, Fish, Alexander, Winterwerp, Herrie HK, Reumer, Annet, Marx, Andreas D, Hermans, Nicolaas, Nicholls, Robert A, Murshudov, Garib N, Lebbink, Joyce HG, Friedhoff, Peter, Sixma, Titia K
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
Assuntos:
Biophysics and Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521584/
https://ncbi.nlm.nih.gov/pubmed/26163658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06744
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