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MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA
To avoid mutations in the genome, DNA replication is generally followed by DNA mismatch repair (MMR). MMR starts when a MutS homolog recognizes a mismatch and undergoes an ATP-dependent transformation to an elusive sliding clamp state. How this transient state promotes MutL homolog recruitment and a...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4521584/ https://ncbi.nlm.nih.gov/pubmed/26163658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06744 |
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