Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation

The process of DNA mismatch repair is initiated when MutS recognizes mismatched DNA bases and starts the repair cascade. The Escherichia coli MutS protein exists in an equilibrium between dimers and tetramers, which has compromised biophysical analysis. To uncouple these states, we have generated st...

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Detalhes bibliográficos
Main Authors: Groothuizen, Flora S., Fish, Alexander, Petoukhov, Maxim V., Reumer, Annet, Manelyte, Laura, Winterwerp, Herrie H. K., Marinus, Martin G., Lebbink, Joyce H. G., Svergun, Dmitri I., Friedhoff, Peter, Sixma, Titia K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783165/
https://ncbi.nlm.nih.gov/pubmed/23821665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt582
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