Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation
The process of DNA mismatch repair is initiated when MutS recognizes mismatched DNA bases and starts the repair cascade. The Escherichia coli MutS protein exists in an equilibrium between dimers and tetramers, which has compromised biophysical analysis. To uncouple these states, we have generated st...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3783165/ https://ncbi.nlm.nih.gov/pubmed/23821665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt582 |
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