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Magnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutS
The DNA mismatch repair protein MutS acts as a molecular switch. It toggles between ADP and ATP states and is regulated by mismatched DNA. This is analogous to G-protein switches and the regulation of their “on” and “off” states by guanine exchange factors. Although GDP release in monomeric GTPases...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857095/ https://ncbi.nlm.nih.gov/pubmed/20167596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.066001 |
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