MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

To avoid mutations in the genome, DNA replication is generally followed by DNA mismatch repair (MMR). MMR starts when a MutS homolog recognizes a mismatch and undergoes an ATP-dependent transformation to an elusive sliding clamp state. How this transient state promotes MutL homolog recruitment and a...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Groothuizen, Flora S, Winkler, Ines, Cristóvão, Michele, Fish, Alexander, Winterwerp, Herrie HK, Reumer, Annet, Marx, Andreas D, Hermans, Nicolaas, Nicholls, Robert A, Murshudov, Garib N, Lebbink, Joyce HG, Friedhoff, Peter, Sixma, Titia K
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2015
Konular:
Biophysics and Structural Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521584/
https://ncbi.nlm.nih.gov/pubmed/26163658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06744
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