Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/K(b) Transgenic Mice May Associate with the Severity of Hemorrhagic Fever with Renal Syndrome

Hantaan virus (HTNV) infections can cause severe hemorrhagic fever with renal syndrome (HFRS) in humans, which is associated with high fatality rates. Cytotoxic T cell (CTL) responses contribute to virus elimination; however, to date, HLA class I allele-restricted HTNV glycoprotein (GP) epitopes rec...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Tang, Kang, Cheng, Linfeng, Zhang, Chunmei, Zhang, Yusi, Zheng, Xuyang, Zhang, Yun, Zhuang, Ran, Jin, Boquan, Zhang, Fanglin, Ma, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732971/
https://ncbi.nlm.nih.gov/pubmed/29312318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01797
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