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Protective CD8+ T-cell response against Hantaan virus infection induced by immunization with designed linear multi-epitope peptides in HLA-A2.1/Kb transgenic mice

Abstract Background An effective vaccine that prevents disease caused by hantaviruses is a global public health priority, but up to now, no vaccine has been approved for worldwide use. Therefore, novel vaccines with high prophylaxis efficacy are urgently needed. Methods Herein, we designed and synth...

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Main Authors: Ying Ma, Kang Tang, Yusi Zhang, Chunmei Zhang, Linfeng Cheng, Fanglin Zhang, Ran Zhuang, Boquan Jin, Yun Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-10-01
Colecção:Virology Journal
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Acesso em linha:http://link.springer.com/article/10.1186/s12985-020-01421-y
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