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HLA-A2 and B35 Restricted Hantaan Virus Nucleoprotein CD8(+) T-Cell Epitope-Specific Immune Response Correlates with Milder Disease in Hemorrhagic Fever with Renal Syndrome
BACKGROUND: Hantaan virus (HTNV) infection in humans is a serious public health concern in Asia. A potent T cell activation peptide vaccine from HTNV structure protein represents a promising immunotherapy for disease control. However, the T cell epitopes of the HTNV restricted by the HLA alleles and...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3585118/ https://ncbi.nlm.nih.gov/pubmed/23469304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002076 |
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