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Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/K(b) Transgenic Mice May Associate with the Severity of Hemorrhagic Fever with Renal Syndrome

Hantaan virus (HTNV) infections can cause severe hemorrhagic fever with renal syndrome (HFRS) in humans, which is associated with high fatality rates. Cytotoxic T cell (CTL) responses contribute to virus elimination; however, to date, HLA class I allele-restricted HTNV glycoprotein (GP) epitopes rec...

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Publicat a:Front Immunol
Autors principals: Tang, Kang, Cheng, Linfeng, Zhang, Chunmei, Zhang, Yusi, Zheng, Xuyang, Zhang, Yun, Zhuang, Ran, Jin, Boquan, Zhang, Fanglin, Ma, Ying
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732971/
https://ncbi.nlm.nih.gov/pubmed/29312318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01797
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