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A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses

In addition to its conventional role for cell proliferation and survival, the Raf/MEK/Extracellular signal-regulated kinase (ERK) pathway can also induce growth arrest and death responses, if aberrantly activated. Here, we determined a molecular basis of ERK1/2 signaling that underlies these growth...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cell Signal
मुख्य लेखकों: Hong, Seung-Keun, Wu, Pui-Kei, Park, Jong-In
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2017
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732048/
https://ncbi.nlm.nih.gov/pubmed/28986121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.10.001
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