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ERK1/2 can feedback-regulate cellular MEK1/2 levels

Signal transduction of the Raf/MEK/ERK pathway is regulated by various feedback mechanisms. Given the greater molar ratio between Raf-MEK than between MEK-ERK in cells, it may be possible that MEK1/2 levels are regulated to modulate Raf/MEK/ERK activity upon pathway stimulation. Nevertheless, it has...

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Detalhes bibliográficos
Publicado no:Cell Signal
Main Authors: Hong, Seung-Keun, Wu, Pui-Kei, Karkhanis, Mansi, Park, Jong-In
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540659/
https://ncbi.nlm.nih.gov/pubmed/26163823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2015.07.003
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