Noncatalytic Function of ERK1/2 Can Promote Raf/MEK/ERK-mediated Growth Arrest Signaling

Kinase activity is known as the key biochemical property of MAPKs. Here, we report that ERK1/2 also utilizes its noncatalytic function to mediate certain signal transductions. Sustained activation of the Raf/MEK/ERK pathway induces growth arrest, accompanied by changes in cell cycle regulators (decr...

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Bibliografiske detaljer
Main Authors: Hong, Seung-Keun, Yoon, Seunghee, Moelling, Cas, Arthan, Dumrongkiet, Park, Jong-In
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785141/
https://ncbi.nlm.nih.gov/pubmed/19805545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.012591
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