Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis

Pyrazinamide (PZA) is a critical component of first- and second-line treatments of tuberculosis (TB), yet its mechanism of action largely remains an enigma. We carried out a genetic screen to isolate Mycobacterium bovis BCG mutants resistant to pyrazinoic acid (POA), the bioactive derivative of PZA,...

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Vydáno v:ACS Infect Dis
Hlavní autoři: Gopal, Pooja, Yee, Michelle, Sarathy, Jickky, Low, Jian Liang, Sarathy, Jansy P., Kaya, Firat, Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731467/
https://ncbi.nlm.nih.gov/pubmed/27759369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00070
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