Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD

Previously, we showed that a major in vitro and in vivo mechanism of resistance to pyrazinoic acid (POA), the bioactive component of the critical tuberculosis (TB) prodrug pyrazinamide (PZA), involves missense mutations in the aspartate decarboxylase PanD, an enzyme required for coenzyme A biosynthe...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Gopal, Pooja, Nartey, Wilson, Ragunathan, Priya, Sarathy, Jansy, Kaya, Firat, Yee, Michelle, Setzer, Claudia, Manimekalai, Malathy Sony Subramanian, Dartois, Véronique, Grüber, Gerhard, Dick, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5734868/
https://ncbi.nlm.nih.gov/pubmed/28991455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00079
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados