Pyrazinamide triggers degradation of its target aspartate decarboxylase

Pyrazinamide is a sterilizing first-line tuberculosis drug. Genetic, metabolomic and biophysical analyses previously demonstrated that pyrazinoic acid, the bioactive form of the prodrug pyrazinamide (PZA), interrupts biosynthesis of coenzyme A in Mycobacterium tuberculosis by binding to aspartate de...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Gopal, Pooja, Sarathy, Jickky Palmae, Yee, Michelle, Ragunathan, Priya, Shin, Joon, Bhushan, Shashi, Zhu, Junhao, Akopian, Tatos, Kandror, Olga, Lim, Teck Kwang, Gengenbacher, Martin, Lin, Qingsong, Rubin, Eric J., Grüber, Gerhard, Dick, Thomas
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125159/
https://ncbi.nlm.nih.gov/pubmed/32245967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15516-1
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