Pyrazinamide triggers degradation of its target aspartate decarboxylase

Pyrazinamide is a sterilizing first-line tuberculosis drug. Genetic, metabolomic and biophysical analyses previously demonstrated that pyrazinoic acid, the bioactive form of the prodrug pyrazinamide (PZA), interrupts biosynthesis of coenzyme A in Mycobacterium tuberculosis by binding to aspartate de...

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Vydáno v:Nat Commun
Hlavní autoři: Gopal, Pooja, Sarathy, Jickky Palmae, Yee, Michelle, Ragunathan, Priya, Shin, Joon, Bhushan, Shashi, Zhu, Junhao, Akopian, Tatos, Kandror, Olga, Lim, Teck Kwang, Gengenbacher, Martin, Lin, Qingsong, Rubin, Eric J., Grüber, Gerhard, Dick, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125159/
https://ncbi.nlm.nih.gov/pubmed/32245967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15516-1
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