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Mycobacterium tuberculosis PanD structure-function analysis and identification of a potent pyrazinoic acid-derived enzyme inhibitor

A common strategy employed in antibacterial drug discovery is targeting of biosynthetic processes which are essential and specific for the pathogen. Specificity in particular avoids undesirable interactions with potential enzymatic counterparts in the human host, and ensures on-target toxicity. Synt...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Ragunathan, Priya, Cole, Malcolm, Latka, Chitra, Aragaw, Wassihun Wedajo, Hegde, Pooja, Shin, Joon, Subramanian Manimekalai, Malathy Sony, Rishikesan, Sankaranarayanan, Aldrich, Courtney C., Dick, Thomas, Grüber, Gerhard
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217388/
https://ncbi.nlm.nih.gov/pubmed/33984234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.1c00131
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