Variations of Subunit ε of the Mycobacterium tuberculosis F(1)F(o) ATP Synthase and a Novel Model for Mechanism of Action of the Tuberculosis Drug TMC207

The subunit ε of bacterial F(1)F(O) ATP synthases plays an important regulatory role in coupling and catalysis via conformational transitions of its C-terminal domain. Here we present the first low-resolution solution structure of ε of Mycobacterium tuberculosis (Mtε) F(1)F(O) ATP synthase and the n...

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Autores principales: Biuković, Goran, Basak, Sandip, Manimekalai, Malathy Sony Subramanian, Rishikesan, Sankaranarayanan, Roessle, Manfred, Dick, Thomas, Rao, Srinivasa P. S., Hunke, Cornelia, Grüber, Gerhard
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535943/
https://ncbi.nlm.nih.gov/pubmed/23089752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01039-12
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