Impact of immunopathology on the antituberculous activity of pyrazinamide

In the 1970s, inclusion of pyrazinamide (PZA) in the drug regimen of tuberculosis (TB) patients for the first 2 mo achieved a drastic reduction of therapy duration. Until now, however, the mechanisms underlying PZA’s unique contribution to efficacy have remained controversial, and animal efficacy da...

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Vydáno v:J Exp Med
Hlavní autoři: Blanc, Landry, Sarathy, Jansy Passiflora, Alvarez Cabrera, Nadine, O’Brien, Paul, Dias-Freedman, Isabela, Mina, Marizel, Sacchettini, James, Savic, Radojka M., Gengenbacher, Martin, Podell, Brendan K., Prideaux, Brendan, Ioerger, Thomas, Dick, Thomas, Dartois, Véronique
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080910/
https://ncbi.nlm.nih.gov/pubmed/30018074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180518
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