Flow Cytometric Detection of PrP(Sc) in Neurons and Glial Cells from Prion-Infected Mouse Brains

In prion diseases, an abnormal isoform of prion protein (PrP(Sc)) accumulates in neurons, astrocytes, and microglia in the brains of animals affected by prions. Detailed analyses of PrP(Sc)-positive neurons and glial cells are required to clarify their pathophysiological roles in the disease. Here,...

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Bibliographic Details
Published in:J Virol
Main Authors: Yamasaki, Takeshi, Suzuki, Akio, Hasebe, Rie, Horiuchi, Motohiro
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Prions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730779/
https://ncbi.nlm.nih.gov/pubmed/29046463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01457-17
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