Enhancement of binding avidity by bivalent binding enables PrP(Sc)-specific detection by anti-PrP monoclonal antibody 132

Anti-prion protein (PrP) monoclonal antibody 132, which recognizes mouse PrP amino acids 119–127, enables us to reliably detect abnormal isoform prion protein (PrP(Sc)) in cells or frozen tissue sections by immunofluorescence assay, although treatment with guanidinium salts is a prerequisite. Despit...

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Vydáno v:PLoS One
Hlavní autoři: Suzuki, Akio, Yamasaki, Takeshi, Hasebe, Rie, Horiuchi, Motohiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553756/
https://ncbi.nlm.nih.gov/pubmed/31170247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217944
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