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Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis
The tumor suppressor p53 is a key regulator of apoptosis induced by various cellular stresses. p53 can induce apoptosis by two mechanisms. First, p53 acts as a transcription factor inducing and repressing pro-apoptotic and anti-apoptotic targets genes, respectively. Second, p53 is able to translocat...
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| Udgivet i: | Cell Death Differ |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5729520/ https://ncbi.nlm.nih.gov/pubmed/28937686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.143 |
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