STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392

Interferon-γ–inducible factor 16 (IFI16) triggers stimulator of interferon (IFN) genes (STING)–dependent type I IFN production during host antiviral immunity and facilitates p53-dependent apoptosis during suppressing tumorigenesis. We have previously reported that STING-mediated IFI16 degradation ne...

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Publicado en:J Biol Chem
Autores principales: Li, Dapei, Xie, Lifen, Qiao, Zigang, Mai, Sanyue, Zhu, Jingfei, Zhang, Fan, Chen, Shengchuan, Li, Liang, Shen, Fangrong, Qin, Yanghua, Yao, Haiping, He, Sudan, Ma, Feng
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8326736/
https://ncbi.nlm.nih.gov/pubmed/34216619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100930
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