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TCR-Induced Akt Serine 473 Phosphorylation Is Regulated by Protein Kinase C-Alpha
Akt signaling plays a central role in T cell functions, such as proliferation, apoptosis, and regulatory T cell development. Phosphorylation at Ser(473) in the hydrophobic motif, along with Thr(308) in its activation loop, is considered necessary for Akt function. It is widely accepted that Phosphoi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2943231/ https://ncbi.nlm.nih.gov/pubmed/20691662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.07.126 |
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