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UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation
Phosphorylation of p53 is a key mechanism responsible for the activation of its tumor suppressor functions in response to various stresses. In unstressed cells, p53 is rapidly turned over and is maintained at a low basal level. After DNA damage or other forms of cellular stress, the p53 level increa...
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| Udgivet i: | Oncotarget |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Impact Journals LLC
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4823074/ https://ncbi.nlm.nih.gov/pubmed/26673821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6555 |
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