Age-dependent effects of apoE reduction using antisense oligonucleotides in a model of β-amyloidosis

The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease. Previous studies suggest reduction of apoE levels through genetic manipulation can reduce Aβ pathology. However, it is not clear how reduction of apoE levels after birth would affect amyloid depos...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Neuron
Päätekijät: Huynh, Tien-Phat V., Liao, Fan, Francis, Caroline M., Robinson, Grace O., Serrano, Javier Remolina, Jiang, Hong, Roh, Joseph, Finn, Mary Beth, Sullivan, Patrick M., Esparza, Thomas J., Stewart, Floy R., Mahan, Thomas E., Ulrich, Jason D., Cole, Tracy, Holtzman, David M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728673/
https://ncbi.nlm.nih.gov/pubmed/29216448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.11.014
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