Age-dependent effects of apoE reduction using antisense oligonucleotides in a model of β-amyloidosis

The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease. Previous studies suggest reduction of apoE levels through genetic manipulation can reduce Aβ pathology. However, it is not clear how reduction of apoE levels after birth would affect amyloid depos...

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Veröffentlicht in:Neuron
Hauptverfasser: Huynh, Tien-Phat V., Liao, Fan, Francis, Caroline M., Robinson, Grace O., Serrano, Javier Remolina, Jiang, Hong, Roh, Joseph, Finn, Mary Beth, Sullivan, Patrick M., Esparza, Thomas J., Stewart, Floy R., Mahan, Thomas E., Ulrich, Jason D., Cole, Tracy, Holtzman, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728673/
https://ncbi.nlm.nih.gov/pubmed/29216448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.11.014
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