Co-occurrence of FLT3-TKD and NPM1 mutations defines a highly favorable prognostic AML group

Although FLT3 internal tandem duplication (ITD) mutations in acute myeloid leukemia (AML) confer an adverse prognosis, co-occurrence with a nucleophosphomin (NPM1) mutation partially improves response and survival outcomes. In contrast, simultaneous NPM1 and FLT3 tyrosine kinase domain (TKD) mutatio...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Boddu, Prajwal, Kantarjian, Hagop, Borthakur, Gautam, Kadia, Tapan, Daver, Naval, Pierce, Sherry, Andreeff, Michael, Ravandi, Farhad, Cortes, Jorge, Kornblau, Steven M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728474/
https://ncbi.nlm.nih.gov/pubmed/29296796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017009019
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