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RNase H sequence preferences influence antisense oligonucleotide efficiency

RNase H cleaves RNA in RNA–DNA duplexes. It is present in all domains of life as well as in multiple viruses and is essential for mammalian development and for human immunodeficiency virus replication. Here, we developed a sequencing-based method to measure the cleavage of thousands of different RNA...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Kiełpiński, Łukasz J., Hagedorn, Peter H., Lindow, Morten, Vinther, Jeppe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728404/
https://ncbi.nlm.nih.gov/pubmed/29126318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1073
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