Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa

Direct factor Xa (FXa) inhibitors lack a specific reversal agent for emergencies such as major bleeding or urgent surgery. Andexanet alfa, a modified, catalytically inactive, recombinant human FXa derivative, reverses anticoagulant effect by binding and sequestering FXa inhibitors. This original rep...

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Vydáno v:Blood Adv
Hlavní autoři: Siegal, Deborah, Lu, Genmin, Leeds, Janet M., Karbarz, Mark, Castillo, Janice, Mathur, Vandana, Hutchaleelaha, Athiwat, Sinha, Uma, Kitt, Michael, McClure, Matt, Hollenbach, Stanley J., Curnutte, John T., Conley, Pamela B., Crowther, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2017
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728098/
https://ncbi.nlm.nih.gov/pubmed/29296829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007112
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