Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors

Anticoagulants such as unfractionated heparin (UFH), low-molecular-weight heparins (LMWHs), fondaparinux, and direct oral anticoagulants (DOACs) targeting thrombin (IIa) or factor Xa (FXa) are widely used in prevention and treatment of thromboembolic disorders. However, anticoagulant-associated blee...

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Bibliographische Detailangaben
Veröffentlicht in:Blood Adv
Hauptverfasser: Kalathottukaren, Manu T., Creagh, A. Louise, Abbina, Srinivas, Lu, Genmin, Karbarz, Mark J., Pandey, Anjali, Conley, Pamela B., Kizhakkedathu, Jayachandran N., Haynes, Charles
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2018
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6113616/
https://ncbi.nlm.nih.gov/pubmed/30135185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016003616
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