X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis. Dysregulation of the plasminogen/plasmin system results in life-threatening hemorrhagic disorders or thrombotic vascular occlusion....

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Law, Ruby H. P., Wu, Guojie, Leung, Eleanor W. W., Hidaka, Koushi, Quek, Adam J., Caradoc-Davies, Tom T., Jeevarajah, Devadharshini, Conroy, Paul J., Kirby, Nigel M., Norton, Raymond S., Tsuda, Yuko, Whisstock, James C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2017
Onderwerpen:
Thrombosis and Hemostasis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728053/
https://ncbi.nlm.nih.gov/pubmed/29296720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016004150
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