Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding

Plasminogen (Plg)-binding M protein (PAM) is a group A streptococcal cell surface receptor that is crucial for bacterial virulence. Previous studies revealed that, by binding to the kringle 2 (KR2) domain of host Plg, the pathogen attains a proteolytic microenvironment on the cell surface that facil...

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Udgivet i:J Mol Biol
Main Authors: Quek, Adam J.H., Mazzitelli, Blake A., Wu, Guojie, Leung, Eleanor W.W., Caradoc-Davies, Tom T., Lloyd, Gordon J., Jeevarajah, Devadharshini, Conroy, Paul J., Sanderson-Smith, Martina, Yuan, Yue, Ayinuola, Yetunde A., Castellino, Francis J., Whisstock, James C., Law, Ruby H.P.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722781/
https://ncbi.nlm.nih.gov/pubmed/31295457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.07.003
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