Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence

Virulent strains of Streptococcus pyogenes (gram-positive group A Streptococcus pyogenes [GAS]) recruit host single-chain human plasminogen (hPg) to the cell surface—where in the case of Pattern D strains of GAS, hPg binds directly to the cells through a surface receptor, plasminogen-binding group A...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ayinuola, Yetunde A., Brito-Robinson, Teresa, Ayinuola, Olawole, Beck, Julia E., Cruz-Topete, Diana, Lee, Shaun W., Ploplis, Victoria A., Castellino, Francis J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948469/
https://ncbi.nlm.nih.gov/pubmed/33208461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016262
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