Paradoxical enhancement of leukemogenesis in acute myeloid leukemia with moderately attenuated RUNX1 expressions

Besides being a classical tumor suppressor, runt-related transcription factor 1 (RUNX1) is now widely recognized for its oncogenic role in the development of acute myeloid leukemia (AML). Here we report that this bidirectional function of RUNX1 possibly arises from the total level of RUNX family exp...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Morita, Ken, Maeda, Shintaro, Suzuki, Kensho, Kiyose, Hiroki, Taniguchi, Junichi, Liu, Pu Paul, Sugiyama, Hiroshi, Adachi, Souichi, Kamikubo, Yasuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727854/
https://ncbi.nlm.nih.gov/pubmed/29296785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007591
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