RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells

The dual function of runt-related transcriptional factor 1 (RUNX1) as an oncogene or oncosuppressor has been extensively studied in various malignancies, yet its role in gastric cancer remains elusive. Up-regulation of the ErbB2/HER2 signaling pathway is frequently-encountered in gastric cancer and...

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Publicado no:Sci Rep
Main Authors: Mitsuda, Yoshihide, Morita, Ken, Kashiwazaki, Gengo, Taniguchi, Junichi, Bando, Toshikazu, Obara, Moeka, Hirata, Masahiro, Kataoka, Tatsuki R., Muto, Manabu, Kaneda, Yasufumi, Nakahata, Tatsutoshi, Liu, Pu Paul, Adachi, Souichi, Sugiyama, Hiroshi, Kamikubo, Yasuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913281/
https://ncbi.nlm.nih.gov/pubmed/29686309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24969-w
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