Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson's Disease

Stereological analysis is the optimal tool for quantitative assessment of brain morphological and cellular changes induced by neurotoxic lesions or treatment interventions. Stereological methods based on random sampling techniques yield unbiased estimates of particle counts within a defined volume,...

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Bibliographic Details
Published in:Front Neuroanat
Main Authors: Fabricius, Katrine, Barkholt, Pernille, Jelsing, Jacob, Hansen, Henrik H.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727600/
https://ncbi.nlm.nih.gov/pubmed/29276478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnana.2017.00109
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