Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity

Large-scale genomic analyses of human cancers have cataloged somatic point mutations thought to initiate tumor development and sustain cancer growth. However, determining the functional significance of specific alterations remains a major bottleneck in our understanding of the genetic determinants o...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Winters, Ian P., Chiou, Shin-Heng, Paulk, Nicole K., McFarland, Christopher D., Lalgudi, Pranav V., Ma, Rosanna K., Lisowski, Leszek, Connolly, Andrew J., Petrov, Dmitri A., Kay, Mark A., Winslow, Monte M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727199/
https://ncbi.nlm.nih.gov/pubmed/29233960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01519-y
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