Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity

Large-scale genomic analyses of human cancers have cataloged somatic point mutations thought to initiate tumor development and sustain cancer growth. However, determining the functional significance of specific alterations remains a major bottleneck in our understanding of the genetic determinants o...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Winters, Ian P., Chiou, Shin-Heng, Paulk, Nicole K., McFarland, Christopher D., Lalgudi, Pranav V., Ma, Rosanna K., Lisowski, Leszek, Connolly, Andrew J., Petrov, Dmitri A., Kay, Mark A., Winslow, Monte M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727199/
https://ncbi.nlm.nih.gov/pubmed/29233960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01519-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados